- Sherlock Holmes: Has almost a superpower-like ability to deduce problems; incredibly observant; arrogant; has somewhat of a God complex; consumed with solving puzzles; when horrible things happen, it's an exciting game for him to figure out; at times cold, calculating, and Machiavellian; peculiar and disregards social expectations (at times he has target practice on the walls of his room); carries a massive and bold presence -- like Superman or Batman, but at times prone to unexpected and unintended physical comedy and exuberant outbursts when excited.
- Dr. Watson: A medical doctor who likes normalcy, his tea, and the possibility of helping people; excited and intrigued by Sherlock; so much so, that he writes about and publishes their adventures for others to read; the closest thing Sherlock has to a friend
- Mrs. Hudson: The landlady of Sherlock Holmes' home -- 221B Baker Street. Despite repeated declarations that she's not Holmes' housekeeper, she still takes care of him in his antics that often distract him from household responsibilities. Sherlock takes it for granted that she makes dinner for him.
- Alice Faulkner: A young, beautiful woman and sister to the Prince's previous girlfriend. She initially plans to avenge her sister's death, but eventually falls in love with Sherlock Holmes. She's passionate, confident, willing to face danger, and a little reckless.
- Forman: An undercover for Sherlock Holmes who assumes butler work for the Larrabees to spy on them and report back info. Claims to have the ability to produce convincing forgeries, which the Larrabees hope can help them in their plans to trap Holmes.
- Teresa: Another one of Holmes' undercover agents working as the Larrabee's maid.
- Lestrade/Inspector: By the book police officer who surprisingly helps Holmes in the end.
Evil Characters
- Professor Moriarty: Psychopath who enjoys causing chaos and destruction. Brilliant and equally arrogant, but bent on evil. He wants immense power and wealth. Intrigued by Holmes' brilliance and fantisizes working together with him, but decides he must get rid of him.
- Madge Larrabee: James' wife. Very much like Madame Thénardier in Les Miserables. Wants to live like the upper crust (with a butler, maid, etc.), but have a lower-class, crook mentality. Tries to act confident, but have no ability to fool Holmes or Moriarty.
- James Larrabee: Madge's husband. Very much like Monsieur Thénardie in Les Miserables. Wants to live like the upper crust (with a butler, maid, etc.), but have a lower-class, crook mentality. Despite trying to act confident, he's a bit oafish and unintelligent.
- Sid Prince: A classic crook and thief with a special talent at cracking locks. Thick Cockney accent, gloves with fingers cut off, etc. Works with Moriarty and stupidly brings the Larrabees to his lair without his consent.
- Joan: Moriarty's aid/secretary. Cold, calculating, down to business. Attracted to Moriarty's power and intelligence.
- Gertie: Hag-like crook who is an arsonist and bomb expert.
- Mrs. Bassick: Head of the street thieves (Ginger, Pepper, Matchgirl, and Flower woman) who has her women act as street sellers and suffragettes to distract pedestrians so that they can pick their pockets. She's strong and demanding and the older one of the bunch.
- Ginger: one of the crooks that plays a suffragette and helps out with other criminal activities
- Pepper: one of the crooks that plays a suffragette and helps out with other criminal activities
- Matchgirl: one of the crooks that plays a street seller and helps out with other criminal activities
- Flower woman: one of the crooks that plays a street seller and helps out with other criminal activities
Additional Characters
- Lady Edwina: Upper crust relative of Prince Carl; a bit over the top; concerned for the Prince
- Prince Carl: Prince of Bohemia who will soon be married, but had a previous relationship with Alice Faulkner's sister and desperately wants his love letters to her back to avoid getting blackmailed
- Gentleman: Gentleman who is accosted by street sellers and pick pocketed
- Elegant Lady: Lady who is accosted by street sellers and pick pocketed
- Newsboy One: Newspaper seller who competes with newsboy two in newspaper sales
- Newsboy Two: Newspaper seller who competes with newsboy one in newspaper sales
- Maggie Baskerville: Frantic woman who seeks Holmes' help at the end of the play
- Other Londoners and Singer(s): Help to fill in during transitional scenes
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